Variational multiple-tensor fitting of fiber-ambiguous diffusion-weighted magnetic resonance imaging voxels

Partial volume effects are often experienced in diffusion-weighted MRI of biologic tissue. This is when the signal attenuation reflects a mixture of diffusion processes, originating from different tissue compartments, residing in the same voxel. Decomposing the mixture requires elaborated models that account for multiple compartments, yet the fitting problem for those models is usually ill posed. We suggest a novel approach for stabilizing the fitting problem of the multiple-tensors model by a variational framework that adds biologically oriented assumption of neighborhood alignments. The framework is designed to address fiber ambiguity caused by a number of neuronal fiber compartments residing in the same voxel. The method requires diffusion data acquired by common, clinically feasible MRI sequences, and is able to derive familiar tensor quantities for each compartment. Neighborhood alignment is performed by adding piece-wise smooth regularization constraints to an energy function. Minimization with the gradient descent method produces a set of diffusion-reaction partial differential equations that describe a tensor-preserving flow towards a best approximation of the data while maintaining the constraints. We analyze fiber compartment separation capabilities on a synthetic model of crossing fibers and on brain areas known to have crossing fibers. We compare the results with diffusion tensor imaging analysis and discuss applications for the framework.     

基于积分观测器实现一类受扰混沌系统的同步

在系统参数和系统输出同时受扰的情形下,基于积分观测器的方法,实现了一类不确定混沌系统的同步.首先利用Lyapunov 稳定性理论,给出了混沌系统同步所需的充分条件,此条件可以快速地实现驱动系统与响应系统的同步,然后结合Schur补定理,将此条件转化为求解线性矩阵不等式组.最后,借助Matlab软件包中的LMI工具箱,通过对受扰MLC电路系统的同步数值仿真,证实了该方法的有效性.     

自由空间量子通讯实验中纠缠源的研制

设计了适合自由空间量子通讯实验的纠缠源. 纠缠光子对的单模光纤搜集率约为每秒20000对,水平竖直方向的纠缠对比度大于95%,正负45°方向的纠缠对比度大于90%. 在本地得到了大于100个标准偏差的Bell 不等式破缺. 满足20 km量级的自由空间量子通讯试验要求. 关键词： 纠缠光子对 位相匹配 收集效率 贝尔不等式     

生成模型在蛋白质序列设计中的应用

蛋白质是一切生命体的物质基础,是生命活动的主要承担者,参与各种生理功能的调节.设计具有特定功能的蛋白质在蛋白质工程、生物医药、材料科学等领域具有重要意义.蛋白质序列设计的目标是设计能够折叠成期望结构并具有相应功能的氨基酸序列,是所有理性蛋白质工程的核心问题,具有极其重要的研究和应用潜力.随着蛋白质序列数据的指数型增长和...     

A Hardy–Trudinger–Moser Inequality Involving LpNorm in the Hyperbolic Space

Let B be the unit disc in R~2, H be the completion of C_0∞(B) under the norm■ .By the method of blow-up analysis and an argument of rearrangement with respect to the standard hyperbolic metric ■, we prove that, for any fixed■ ,the supremum■ .This is an analog of early results of Lu–Yang(Discrete Contin. Dyn. Syst., 2009) and Yang(Trans.Amer. Math. Soc., 2007), and extends those of Wang–Ye(Adv. Math., 2012) and Yang–Zhu(Ann.Global Anal. Geom., 2016).     

Uniqueness in Harper’s vertex-isoperimetric theorem

For a set $A\subseteq Q_n={\left\{0,1\right\}}^n$ the $t$-neighbourhood of $A$ is $N^t\left(A\right)=\left\{x:d\left(x,A\right)\le t\right\}$, where $d$ denotes the usual graph distance on $Q_n$. Harper’s vertex-isoperimetric theorem states that among the subsets $A\subseteq Q_n$ of given size, the size of the $t$-neighbourhood is minimised when $A$ is taken to be an initial segment of the simplicial order. Aubrun and Szarek asked the following question: if $A\subseteq Q_n$ is a subset of given size for which the sizes of both $N^t\left(A\right)$ and $N^t\left(A^c\right)$ are minimal for all $t>0$, does it follow that $A$ is isomorphic to an initial segment of the simplicial order?Our aim is to give a counterexample. Surprisingly it turns out that there is no counterexample that is a Hamming ball, meaning a set that lies between two consecutive exact Hamming balls, i.e. a set $A$ with $B\left(x,r\right)\subseteq A\subseteq B\left(x,r+1\right)$ for some $x\in Q_n$. We go further to classify all the sets $A\subseteq Q_n$ for which the sizes of both $N^t\left(A\right)$ and $N^t\left(A^c\right)$ are minimal for all $t>0$ among the subsets of $Q_n$ of given size. We also prove that, perhaps surprisingly, if $A\subseteq Q_n$ for which the sizes of $N\left(A\right)$ and $N\left(A^c\right)$ are minimal among the subsets of $Q_n$ of given size, then the sizes of both $N^t\left(A\right)$ and $N^t\left(A^c\right)$ are also minimal for all $t>0$ among the subsets of $Q_n$ of given size. Hence the same classification also holds when we only require $N\left(A\right)$ and $N\left(A^c\right)$ to have minimal size among the subsets $A\subseteq Q_n$ of given size.     

A normalized solitary wave solution of the Maxwell-Dirac equations

We prove the existence of a $L^2$-normalized solitary wave solution for the Maxwell-Dirac equations in (3+1)-Minkowski space. In addition, for the Coulomb-Dirac model, describing fermions with attractive Coulomb interactions in the mean-field limit, we prove the existence of the (positive) energy minimizer.     

Sobolev-Lorentz范数约束下的次临界型Adams不等式

本文在Sobolev-Lorentz空间W²L^2,q(R⁴)的范数约束下得到了一个最佳的二阶次临界型Adams不等式.进一步,当次临界指标逼近最佳常数时,得到了Adams泛函的上、下界的估计.本文主要采用了Lam和Lu[A new approach to sharp MoserTrudinger and Adams type inequalities:a rearrangement-free argument,J.Diff Equ.,2013,255(3):298-325]的分割水平集方法.     

Analysis of a new multispecies tumor growth model coupling 3D phase-fields with a 1D vascular network

In this work, we present and analyze a mathematical model for tumor growth incorporating ECM erosion, interstitial flow, and the effect of vascular flow and nutrient transport. The model is of phase-field or diffused-interface type in which multiple phases of cell species and other constituents are separated by smooth evolving interfaces. The model involves a mesoscale version of Darcy’s law to capture the flow mechanism in the tissue matrix. Modeling flow and transport processes in the vasculature supplying the healthy and cancerous tissue, one-dimensional (1D) equations are considered. Since the models governing the transport and flow processes are defined together with cell species models on a three-dimensional (3D) domain, we obtain a 3D–1D coupled model.